Impact of Pathological Vascular Remodelling on Right Ventricular Mechanics

Abstract Pulmonary arterial hypertension (PAH) is a rare disorder characterized by elevated blood pressure and pulmonary vascular resistance, often followed right ventricular hypertrophy heart failure. The effect of PAH its treatments on the mechanics, function, remodelling ventricle (RV) currently not well understood. To study cardiac biomechanics functionality as progresses, we implemented computational model simulating maladaptive remodelling. Our Windkessel-based model, which accounts for direct interaction presence pericardium, utilized to simulate various disease stages PAH. We find that pericardium has larger performance than through septum.We also examined effectiveness two treatments, assist device (RVAD) atrial septostomy, diseased hearts. show while both pulsatile continuous RVADs restore RVAD improves output 29.4% more RVAD. demonstrate septostomy 19.5%. can be further extended heart’s response other such extracorporeal membrane oxygenation (ECMO), incorporating growth simulations finite-element modelling.